The effects of kappa-opioid receptor ligands on prepulse inhibition and CRF-induced prepulse inhibition deficits in the rat
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چکیده
منابع مشابه
Prepulse-elicited startle in prepulse inhibition.
BACKGROUND Prepulse inhibition (PPI) has become a major experimental paradigm in the study of psychiatric disorders. In this study, a potential confound in measurement and interpretation of PPI, namely startle reactions to so-called "nonstartling" prepulses, was examined. METHODS Prepulses of 80, 85, and 90 dB(A) were presented on their own or followed by a pulse of 115 dB(A) (lead interval: ...
متن کاملEffects of the Antioxidant Sulforaphane on Hyperlocomotion and Prepulse Inhibition Deficits in Mice after Phencyclidine Administration
OBJECTIVE Accumulating evidence suggests that oxidative stress plays a role in the pathophysiology of schizophrenia and that the potent antioxidants may be potential therapeutic drugs for schizophrenia. This study was undertaken to examine the effects of the potent antioxidant sulforaphane (SFN), found in cruciferous vegetables, on behavioral abnormalities (e.g., hyperlocomotion and prepulse in...
متن کاملEffective neuroleptic medication removes prepulse inhibition deficits in schizophrenia patients.
BACKGROUND The magnitude of the startle eyeblink response is reduced if the startle eliciting stimulus is shortly preceded by another stimulus. There is evidence that schizophrenia patients exhibit impairments in this so-called prepulse inhibition. Our study investigated whether prepulse inhibition is affected by neuroleptic drug treatment as is suggested by animal research. METHODS Prepulse ...
متن کاملEffects of early acoustic stimulation on prepulse inhibition in mice
The purpose of this study was to determine the effects of an atypical pattern of early acoustic stimulation on auditory development. Previous human research suggests that the acoustic environment of pre-term human infants in the Neonatal Intensive Care Unit (NICU) negatively affects some aspects of auditory development. Animal research suggests that premature auditory stimulation interrupts aud...
متن کاملPrepulse inhibition of the Tritonia escape swim.
Presenting a weak stimulus just before a strong, startle stimulus reduces the amplitude of the ensuing startle response in humans and other vertebrates. This phenomenon, termed "prepulse inhibition" (PPI), appears to function to reduce distraction while processing sensory input. To date, no detailed neural mechanism has been described for PPI. Here we demonstrate PPI in the marine mollusk Trito...
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ژورنال
عنوان ژورنال: Psychopharmacology
سال: 2010
ISSN: 0033-3158,1432-2072
DOI: 10.1007/s00213-010-1799-6